Fentanyl was manufactured by Dr. Paul Janssen in 1959 and used to effectively treat acute, persistent, and non-responsive pain. A transdermal patch was created in the 1990s and is currently frequently oxycodone for sale recommended for patients with chronic pain. Right after, the blue fentanyl and fentanyl oral were created as delivery systems for breakthrough pain relief. All have triggered abuse, but nowadays, analogs are frequently utilized to create new, difficult-to-detect compounds, confusing public health officials and law enforcement and posing a better danger to make use of and addiction.